BREAST CANCER SCREENING

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My hope with this article is to give women information that may help them make informed decisions regarding the types of screening for breast cancer they choose to use.  The current common methods of breast tissue screening are self-examination, mammography, ultrasound and MRIs. As MRIs are not readily available, they will not be included in the discussion below. 

Mammography is familiar to most women.  It can pick up lesions as small as 0.5 cm, which you are usually not able to feel, and detects approximately 85% of cancers.  An experienced doctor can pick up 61-92% of lumps.  One of the shortcomings for mammograms is that they are less effective in the following cases: dense or fibrocystic breasts, small or very large breasts, women under age 50, postoperative scarring, exposure to acute/chronic radiation, and if receiving hormone replacement.  They will miss cancers 9-20% of the time in younger women with dense breasts and up to 25% of tumors in women 40-49 years old.

Prolific author Dr. John Lee, MD points out that the “lag time between cancer inception and diagnosis, even by mammograms, may well be over eight years… [and] diagnosis by palpation (self breast exams) can be made about one year later.” He questions that if cancer is prone to spreading (metastasis), would this not likely occur during years prior to the mammogram? He suggests that the evidence that this one-year difference in time of diagnosis will make any difference is lacking. He concludes that the jury on mammograms is still out, but his hunch is that a good self-exam would be as effective as a mammography.

Risks of Radiation.  Radiation from a mammogram is classified as 0.2 or a low dose; it is equal to radiation received from a transcontinental flight, only that this amount is all focused on the breasts.  Some authors claim there is no safe dose, others disagree. Dr. John Gofman, MD, Phd and author of "How to Estimate a Personal Radiation Risk from Mammography" calculates the lifetime risk of 15 mammograms for a woman, beginning at the age of 50. The result is a lifetime risk of 1 in 136 of contracting radiation-induced breast cancer. His findings are based on his own research and assumptions.

The Mortality Paradox.  Dr. Cornelia Baines, MD, in the Journal of the national Cancer Institute 2003 published an article highlighting the results of two Canadian trials and five Swedish trials which together suggest that “up to 11 years after the initiation of screening in women aged 40-49 years, screened women face a higher death rate from breast cancer than unscreened control women.” She also sites a 2001 study showing that surgical removal of primary breast tumors from premenopausal women with involved lymph nodes may trigger the growth of temporarily dormant micrometastases in 20% of patients.  In 1996 a panel of experts for the National Institute of Health concluded that there was not enough evidence to support a recommendation that women in their forties should get routine mammograms. Please see the website http://jncicancerspectrum.oxfordjournals.org for Dr. Baines article as well as Dr. Alfred Berg’s article with counterpoints to her article.

Well known author Dr. Christiane Northrup, MD admits that doctors push mammograms because of the lawsuit-driven medical system.  While she does prescribe regular mammograms she admits she cannot guarantee their absolute safety and that she respects the informed decision of her patients who opt out of mammograms.  Dr. Northrup further admits that when it comes to mammograms “fear and the feeling of helplessness are indeed very detrimental to health” in the context of both a diagnosis for cancer as well as the reports often seeming “punitive and confusing”.

The DCIS Dilemma.  Mammograms can detect early abnormalities that may never become invasive, often know as ductal carcinoma-in-situ (DCIS).  Dr. H. Gilbert Welch cites a study showing that in breasts of women who died from other causes, “40 percent had microscopic precancerous changes in their breasts.” He adds that it is well documented that most women diagnosed with DCIS do not develop invasive breast cancer.  The Journal of American Medical Association reports that the incidence of DCIS has increased dramatically due to mammography screening, but the value of its detection is still unknown.  The proportion of these cases treated by mastectomy may be inappropriately high. What is being suggested here is that early screening may be leading to unnecessary treatments in women that would otherwise have survived without detection?  This is a true dilemma.

What Other Choices do Women Have?  High-resolution breast ultrasound may be a good alternative for some women.  It is very effective at distinguishing between a benign cyst and a solid mass and is 98% effective in distinguishing between a benign lesion and malignant oneThis may be a great option for women for whom mammograms are less accurate for the reasons described earlier.  There is no radiation from ultrasound.

What about Thermography? This technique of breast screening is often supported by alternative practitioners.  Unlike current tools (mammography, ultrasound, MRIs) that detect structural changes, thermography uses digital infrared cameras and a computer program to take heat pictures of the breast tissue.  This monitors functional changes of the breast tissue based on skin temperature changes that reflect the metabolic character of underlying tissues.  It can detect breast tissue changes 5-8 years prior to the development of a mass large enough to be seen with mammography or ultrasound.  It is completely safe and non invasive.  Thermography is not diagnostic of breast cancer and must be followed by conventional methods if an abnormality is found.  Its main advantages are that it is equally useful for all types of breasts regardless of age, density or use of hormones.  Please see www.medthermonline.com for more details.

Preventing Breast Cancer. I would like to emphasize that breast self-exams and mammograms are not preventative measures.  These practices may give many women a false sense of security.   Key to breast cancer prevention is diet, exercise, quitting smoking, limiting the amount of chemicals we expose our bodies to, limiting radiation exposure, and cultivating a peaceful relationship with our bodies. This is where naturopathic medicine plays a very valuable role.  While I hope this article was helpful I suggest that it be used only as a guide to spark your own further research.  My only wish is that women’s decisions are informed, no matter what those decisions may be. 

One of the most frequent questions I am asked as a clinical thermographer is: “What exactly is the difference between mammography, ultrasound and thermography?” There seems to be some confusion on this subject by thinking that one replaces the other as tests, nothing could be further from the truth. Both mammography and ultrasound are structural (anatomical) tests, while thermography is a functional (physiological) test. None of these tests are truly diagnostic technologies. Thermography images the breast and surrounding area and provides us with risk assessment, while mammography and ultrasound detect structural abnormalities. If a breast abnormality is found that could possibly be malignant, a biopsy is performed. A biopsy removes a tissue sample for examination under a microscope.

Many women after their initial assessment with thermography may be asked to follow up either with an ultrasound or mammogram or both to rule out the existing pathology. Frequently some will be relieved that their mammogram or ultrasound test results show no abnormal findings, however this does not necessarily mean that nothing is going on with their breasts. Several other factors may be contributing to a high risk (abnormal) thermogram, such as: hormonal imbalance, early angiogenesis (proliferation of blood vessels), lymphatic swellings and poor function and other contributing factors – all of these are important contributors to breast disease and malignancy and are not detected by mammography or ultrasound as these factors do not appear as structural changes.

One of the most frequent questions I am asked as a clinical thermographer is: “What exactly is the difference between mammography, ultrasound and thermography?” There seems to be some confusion on this subject by thinking that one replaces the other as tests, nothing could be further from the truth. Both mammography and ultrasound are structural (anatomical) tests, while thermography is a functional (physiological) test. None of these tests are truly diagnostic technologies. Thermography images the breast and surrounding area and provides us with risk assessment, while mammography and ultrasound detect structural abnormalities. If a breast abnormality is found that could possibly be malignant, a biopsy is performed. A biopsy removes a tissue sample for examination under a microscope.

Many women after their initial assessment with thermography may be asked to follow up either with an ultrasound or mammogram or both to rule out the existing pathology. Frequently some will be relieved that their mammogram or ultrasound test results show no abnormal findings, however this does not necessarily mean that nothing is going on with their breasts. Several other factors may be contributing to a high risk (abnormal) thermogram, such as: hormonal imbalance, early angiogenesis (proliferation of blood vessels), lymphatic swellings and poor function and other contributing factors – all of these are important contributors to breast disease and malignancy and are not detected by mammography or ultrasound as these factors do not appear as structural changes.

The following is a list comparing all three types of tests with their pros and cons:

 (This is taken from an article by Alexander Mostovoy in his article "Thermography, Mammography or Ultrasound?"  published in Human Spirit Magazine Spring/Summer 2007)

Mammography
  • Structural test: can pinpoint the location of suspicious area
  • Compresses the breast
  • X-ray radiation produces an image; the area of concern must have greater density to stand out against regular tissue
  • Can detect tumors in mainly slow growing stage or pre-invasive stage
  • Cannot detect fast growing tumors in the pre-invasive stage
  • The use of hormones decreases sensitivity
  • Large, dense and fibrocystic breasts are difficult to read
  • The upper portions of the breast including the tail of the breast and the Axillary region cannot be visualized
  • Can detect tumors 1-2 years earlier than physical examination
  • Average Specificity 75% (25% false-positive) 9 out of 10 biopsies initiated by mammography are negative
  • Average Sensitivity 80% with 20% of cancers missed in women over age 50 in women under age 50 Sensitivity is 60% or 40% of cancers missed
Ultrasound
  • Structural test, can pinpoint the location of suspicious area
  • Uses sound waves with moderate contact
  • High frequency sound waves are bounced off the breast tissue and collected as an echo to produce an image
  • Able to detect some tumors missed by mammography
  • No data available on detecting pre-invasive tumors
  • May be affected by the hormonal influence due to the menstrual cycle, (i.e. cystic changes)
  • All areas of the breast and Axillary region can be analyzed
  • Good for distinguishing between solid and fluid masses, helpful in investigating an area of concern due to mammography, thermography or physical examination findings
  • Average Specificity 66% (34% false positive)
  • Average Sensitivity 83% (17% of cancers missed)
Thermography
  • Functional testing, able to detect physiological changes, cannot pinpoint the exact location of suspicious area
  • No radiation, non-invasive, no risk, can be used as often as necessary to observe the effectiveness of treatment over time
  • Uses infrared detectors to detect heat and increased vascularity that may be related to angiogenesis
  • Can detect physiological changes many years prior to any other method of screening
  • Very sensitive to fast growing aggressive tumors
  • Hormonal activity in the breast will affect thermographic imaging but not to the point of abnormality
  • All breast shapes, conditions and areas are within the scope of imaging
  • Earliest warning system with breast tissue and physiological changes that usually precedes tumor formation years prior to its occurrence
  • Average Specificity 90% (10% false positive)
  • Average Sensitivity 90% (10% cancers missed) most of these are slow growing tumors with low metabolic rate in the area with a high rate of survival

 

 

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